A focus of our laboratory is understanding the regulation of pulmonary blood vessels by hypoxia, including non-canonical intrapulmonary shunt vessels. While we still don’t understand a lot about their structure, we recently found that they are regulated (in part) by the beta-2 adrenergic pathway. Beta-2 adrenergic receptors cause dilation (or widening) of blood vessels in the body. Blocking these receptors prevents intrapulmonary shunt vessels from being fully recruited. This is important because opening these pathways may compromise oxygen uptake, which is a major function of the lung.
There is a lot about these pathways that we still don’t understand. Our current interest is motivated by their identification in the lungs of infants and adults that have died of pulmonary hypertension. We hope that by studying their regulation, we can better understand the role they play in lung disease and develop new treatments for these patients.
This week the lab will be traveling to the Experimental Biology meeting in Chicago and we have a lot to celebrate (pics forthcoming)!!
Undergraduate student Matt won a Bruce abstract award and will receive his award at the meeting. Shilpa, another undergraduate and founding member of the lab, has been accepted into Physician Assistant’s school. She’ll be leaving Iowa City to start this new adventure right after graduation. We are so proud of our research team members’ accomplishments!
Also this week, renowned physiologist and all-around great guy David Poole visited from Kansas State University. He gave the 25th annual Louis Alley Lecture in the Department of Health and Human Physiology titled “Muscle Vascular O2 Transport: Myths and Mechanisms.” After his fantastic seminar, he joined the lab and Dr. Amy Sindler’s lab to share his science wisdom. Thanks for coming to Iowa, Dr. Poole!
We are pleased to announce that we have received a one-year, $60,000 seed grant to examine the environmental and genetic determinants underlying the transition of of MGUS into multiple myeloma. MGUS is a precursor, pre-malignant condition that occurs before the development of multiple myeloma. The majority of MGUS cases are benign, but can be devastating when it develops into multiple myeloma. Risk factors for MGUS and myeloma are age, sex, race and obesity and there is currently no cure for myeloma. In a collaboration with Dr. Gail Bishop, we will use these funds to investigate the causes behind malignant transformation. Based on a theory advanced by Dr. Bates, we will investigate a potential association between myeloma and sleep apnea. The short-term goal of this collaborative effort is to determine the effect of intermittent hypoxia on the immune system and on pre-malignant plasma cells.
As a National Cancer Institute-designated comprehensive cancer center, the Holden Comprehensive Cancer Center at the University of Iowa is empowered to fund a variety of mission-aligned developmental research projects (such as this one) through its NCI award. Every comprehensive cancer center including the University of Iowa’s HCCC stresses the importance of multidisciplinary approaches in research and care, ensuring greater productivity and a faster translation of discoveries into more effective treatments.
Work completed with our collaborators in Naomi Chesler’s laboratory has been accepted for publication in the Journal of Biomechanics! The paper titled “Pulmonary arterial strain- and remodeling-induced stiffening are differentiated in a chronic model of pulmonary hypertension ” reports our finding that chronic thromboembolic pulmonary hypertension causes stiffening of the large elastic arteries and that this is correlated with changes in their structure.
Pulmonary hypertension is high blood pressure in the lung vessels that can ultimately lead to heart failure. There is currently no cure for pulmonary hypertension and the prognosis for these patients is pretty grim. 66% of patients die within five years of their diagnosis. Understanding the factors that contribute to the development of pulmonary hypertension will hopefully lead to new treatments for this devastating.
Multiple myeloma is an incurable plasma cancer and the second most common blood malignancy. We have been interested in the role oxygen plays in mediating the progression of this disease and our new collaboration with the Translational Myeloma Group at the University of Iowa has yielded it’s first publication in the journal Oncotarget. We are glad to have had the opportunity to help the Zhan Laboratory with the effort. Our paper titled “Alteration of Mitochondrial Biogenesis Promotes Disease Progression in Multiple Myeloma” should be available soon!
Last week Dr. Bates received an email from Drs. Peter Wagner and Jason H.T. Bates, Editor and Deputy Editor of the Journal of Applied Physiology (JAPPL), inviting her to join the journal’s editorial board. Here’s how the journal describes its mission:
The Journal of Applied Physiology publishes original papers that deal with diverse areas of research in applied physiology, especially those papers emphasizing adaptive and integrative mechanisms. Adaptive physiology includes 1) inherent adaptations such as those related to development, aging, and pathophysiological conditions and 2) adaptations to the external environment such as those occurring with exercise, microgravity, hypoxia, hypo- and hyperbaria, and hypo- and hyperthermic conditions. Integrative physiology includes 1) horizontal integration across organ systems and 2) vertical integration from molecule to cell to organ. In all areas of applied physiology, the use of cutting-edge techniques including molecular and cellular biology is strongly encouraged.
As a graduate student and postdoctoral fellow, having a paper published in JAPPL was a serious goal, so this feels like quite an honor. JAPPL is among the best journals in physiology with a long history of publishing the cornerstone studies in respiratory physiology. Dr. Bates is grateful and humbled by the opportunity to serve the journal.
Summer research student Amy Kaplan emailed us to let us know that she had been offered early acceptance to Tufts University! Amy joined our group as part of the Secondary Student Training Program (SSTP) at the University of Iowa and spent the summer studying the long-term effects of supplemental oxygen on pediatric physiology. The SSTP program gives high school students the opportunity to work in a university laboratory for the summer, gaining research experience and getting a leg up on college life. Her work was presented at the end-of-summer SSTP symposium and the FASEB summer research conference.
We wish Amy the best of luck and know that she has a bright future ahead of her!! Way to go, rockstar!
We feel fortunate to be the proud recipients of an American Cancer Society Seed Grant to continue our work investigating how obesity promotes hematological malignancy (cancer of the blood). This grant is administered through the Holden Comprehensive Cancer Center at the University of Iowa and will provide us with the resources to really take this line of research to the next level. Dr. Bates is looking forward to joining the fight to prevent cancer and develop new treatments for patients in need!
Michael Hoover, Sandeep Kowkuntla, Shreya Chandrasekar, Austin Murphy, Matthew Peters, and Madison Sturgeon traveled with Drs. Bates and Tomasson to the Iowa Physiological Society meeting at Des Moines University!
In addition to poster presentations, Matthew Peters was invited to give a talk on his work in premature infants.
The lab had a very successful time at the meeting! Matthew Peters won an award for his presentation, and Madison Sturgeon and Sandeep Kowkuntla won awards for excellent poster presentations! Alex Brodjeski from the Sindler Lab also won a poster award for his work!
Our new paper titled “Oxidative stress augments chemoreflex sensitivity in rats exposed to chronic intermittent hypoxia” with Barbara Morgan, Rodrigo Del Rio, Zunyi Wang and John Dopp has been accepted in the journal of Respiratory Physiology and Neurobiology! In this paper, we found that exposure to intermittent hypoxia, simulating sleep apnea, increases the sensitivity of the chemoreflex. Increased sensitivity of the chemoreflex may further promote sleep disordered breathing, but this is essentially eliminated by antioxidants and angiotensin II receptor antagonists. This is exciting because it offers insight into future studies of a potential therapy for people with sleep apnea!