Drs. Bates and Tomasson, in collaboration with other investigators from the University of Iowa multiple myeloma group, have been awarded a one year grant to study the factors that drive the transition from pre-malignancy to malignancy in multiple myeloma. This award extends the lab’s current history of work in myeloma treatment and prevention, will provide the framework for studying the interaction between genetic mutations and environmental stressors.
We look forward to this exciting opportunity to continue our work!!!!
We are pleased to announce the publication of our most recent paper titled “Prevention Is the Best Treatment: The Case for Understanding the Transition from Monoclonal Gammopathy of Undetermined Significance to Myeloma,” which is free to view here.
Screening and prevention strategies have been used successfully in some solid tumor cancers, including breast, colon, and prostate. Multiple Myeloma is essentially always preceded by a non-malignant precursor stage called Monoclonal Gammopathy of Undetermined Significance (MGUS). We believe that if we could identify ways to prevent the transition from pre-malignant MGUS to myeloma, we could reduce the personal, societal and economic burden of this devastating blood cancer. In our paper, we review some possible prevention strategies. We also provide the first data on the incidence of sleep-disordered breathing and daytime sleepiness in myeloma patients, and comprehensively detail the multi-million dollar cost of treating this disease.
Thank you to all the lab members and collaborators who contributed to this effort. We hope this paper will be helpful to the scientific and patient community, and to find others who also believe that prevention is the best treatment.
Last week our lab came together in the Clinical Research Unit at the University of Iowa to film the online supplement to our paper titled “Combining volumetric capnography and barometric plethysmography to measure the lung structure-function relationship.” This method allows the investigator to measure the volume of the airways at different lung volumes, to more comprehensively evaluate the lung. As we say in the paper…
This may be a valuable tool for investigators aiming to quantify the influence of airways mechanics versus lung compliance and elastance on pulmonary function in healthy and diseased populations. Furthermore accounting for the absolute lung volume at which the… measurements are being performed allows investigators to characterize the effects of conditions that can alter the inflation state of the lung, such as obesity, lung transplant, or interventions like chest wall strapping. [This method] may ultimately have clinical utility in the intensive care setting.
The paper is in-press with the Journal of Visualized Experiments and will be available soon. Thanks to our collaborators and lab members who came out and contributed to the process!
Today members of the lab took a momentary break from the daily grind of research to celebrate Halloween. Each lab member seems to have independently chosen a scientist-type get-up, with Professor Bates and grad student Hannah choosing a Rick and Morty themed outfit. Hannah, however, truly paid homage to the new cult class by bringing her own Morty as an accessory. Rotating Ph.D. student Adam shined as Bill Nye and Professor Tomasson stretched beyond his comfort zone and dressed as a physician scientist.
A focus of our laboratory is understanding the regulation of pulmonary blood vessels by hypoxia, including non-canonical intrapulmonary shunt vessels. While we still don’t understand a lot about their structure, we recently found that they are regulated (in part) by the beta-2 adrenergic pathway. Beta-2 adrenergic receptors cause dilation (or widening) of blood vessels in the body. Blocking these receptors prevents intrapulmonary shunt vessels from being fully recruited. This is important because opening these pathways may compromise oxygen uptake, which is a major function of the lung.
There is a lot about these pathways that we still don’t understand. Our current interest is motivated by their identification in the lungs of infants and adults that have died of pulmonary hypertension. We hope that by studying their regulation, we can better understand the role they play in lung disease and develop new treatments for these patients.
This week the lab will be traveling to the Experimental Biology meeting in Chicago and we have a lot to celebrate (pics forthcoming)!!
Undergraduate student Matt won a Bruce abstract award and will receive his award at the meeting. Shilpa, another undergraduate and founding member of the lab, has been accepted into Physician Assistant’s school. She’ll be leaving Iowa City to start this new adventure right after graduation. We are so proud of our research team members’ accomplishments!
Also this week, renowned physiologist and all-around great guy David Poole visited from Kansas State University. He gave the 25th annual Louis Alley Lecture in the Department of Health and Human Physiology titled “Muscle Vascular O2 Transport: Myths and Mechanisms.” After his fantastic seminar, he joined the lab and Dr. Amy Sindler’s lab to share his science wisdom. Thanks for coming to Iowa, Dr. Poole!
We are pleased to announce that we have received a one-year, $60,000 seed grant to examine the environmental and genetic determinants underlying the transition of of MGUS into multiple myeloma. MGUS is a precursor, pre-malignant condition that occurs before the development of multiple myeloma. The majority of MGUS cases are benign, but can be devastating when it develops into multiple myeloma. Risk factors for MGUS and myeloma are age, sex, race and obesity and there is currently no cure for myeloma. In a collaboration with Dr. Gail Bishop, we will use these funds to investigate the causes behind malignant transformation. Based on a theory advanced by Dr. Bates, we will investigate a potential association between myeloma and sleep apnea. The short-term goal of this collaborative effort is to determine the effect of intermittent hypoxia on the immune system and on pre-malignant plasma cells.
As a National Cancer Institute-designated comprehensive cancer center, the Holden Comprehensive Cancer Center at the University of Iowa is empowered to fund a variety of mission-aligned developmental research projects (such as this one) through its NCI award. Every comprehensive cancer center including the University of Iowa’s HCCC stresses the importance of multidisciplinary approaches in research and care, ensuring greater productivity and a faster translation of discoveries into more effective treatments.
Work completed with our collaborators in Naomi Chesler’s laboratory has been accepted for publication in the Journal of Biomechanics! The paper titled “Pulmonary arterial strain- and remodeling-induced stiffening are differentiated in a chronic model of pulmonary hypertension ” reports our finding that chronic thromboembolic pulmonary hypertension causes stiffening of the large elastic arteries and that this is correlated with changes in their structure.
Pulmonary hypertension is high blood pressure in the lung vessels that can ultimately lead to heart failure. There is currently no cure for pulmonary hypertension and the prognosis for these patients is pretty grim. 66% of patients die within five years of their diagnosis. Understanding the factors that contribute to the development of pulmonary hypertension will hopefully lead to new treatments for this devastating.
Multiple myeloma is an incurable plasma cancer and the second most common blood malignancy. We have been interested in the role oxygen plays in mediating the progression of this disease and our new collaboration with the Translational Myeloma Group at the University of Iowa has yielded it’s first publication in the journal Oncotarget. We are glad to have had the opportunity to help the Zhan Laboratory with the effort. Our paper titled “Alteration of Mitochondrial Biogenesis Promotes Disease Progression in Multiple Myeloma” should be available soon!
Last week Dr. Bates received an email from Drs. Peter Wagner and Jason H.T. Bates, Editor and Deputy Editor of the Journal of Applied Physiology (JAPPL), inviting her to join the journal’s editorial board. Here’s how the journal describes its mission:
The Journal of Applied Physiology publishes original papers that deal with diverse areas of research in applied physiology, especially those papers emphasizing adaptive and integrative mechanisms. Adaptive physiology includes 1) inherent adaptations such as those related to development, aging, and pathophysiological conditions and 2) adaptations to the external environment such as those occurring with exercise, microgravity, hypoxia, hypo- and hyperbaria, and hypo- and hyperthermic conditions. Integrative physiology includes 1) horizontal integration across organ systems and 2) vertical integration from molecule to cell to organ. In all areas of applied physiology, the use of cutting-edge techniques including molecular and cellular biology is strongly encouraged.
As a graduate student and postdoctoral fellow, having a paper published in JAPPL was a serious goal, so this feels like quite an honor. JAPPL is among the best journals in physiology with a long history of publishing the cornerstone studies in respiratory physiology. Dr. Bates is grateful and humbled by the opportunity to serve the journal.