Tyler Greiner Gives Platform and Poster Presentation at EB2016

Post-baccalaureate student and Health and Human Physiology graduate Tyler Greiner presented his study titled “Pulmonary and Systemic Vascular Responses in Rats Exposed to Perinatal Hyperoxia” at the 2016 Experimental Biology in San Diego. Tyler was invited to present a poster and give a talked during the feature topics session on Origins of Adult Cardiovascular and Metabolic Disease.

Tyler at Poster

He also got a chance to check out some other awesome presentations.

Tyler and Nitin

This achievement reflects Tyler’s year of hard work in the laboratory. He’ll be leaving to attend medical school in the summer. You can read more about Tyler’s study at Pascale Lane’s blog WhizBang.

Paper on Chronic Intermittent Hypoxia and Ventilation Published in the Journal of Applied Physiology

Complications of Sleep Apnea

Our paper with collaborators Barb Morgan, Russ Adrian, Zun-yi Wang and John Dopp titled “Chronic intermittent hypoxia alters ventilatory and metabolic responses to acute hypoxia in rats” was accepted in the Journal of Applied Physiology this week.

Patients with sleep apnea experience periods during sleep where breathing stops. This can occur as many as 60 times per hour. These apneas, which cause periodic, intermittent falls in blood oxygen (hypoxia), can contribute to hypertension, obesity, cancer, and other diseases. It is also unknown  whether having these apneas alters the neural circuitry that controls ventilation and promotes more apneas.  Our study addresses the controversy of whether chronic exposure to intermittent hypoxia enhances ventilatory chemosensitivity. We quantified hypoxic chemosensitivity in conscious rats using a novel method which—unlike most previously published approaches—was able to uncover key effects of prolonged intermittent hypoxia on both metabolic and ventilatory responses to acute hypoxia. We found that hypoxic chemosensitivity is indeed enhanced by intermittent hypoxia and thus is a potentially important contributor to sleep disordered breathing in humans.