We are pleased to announce that Hannah Welper has joined the lab this semester as a master’s thesis student! Hannah has already worked to establish expertise in hypoxia and multiple myeloma and will be looking at factors that impact the tumor microenvironment.
Work completed with our collaborators in Naomi Chesler’s laboratory has been accepted for publication in the Journal of Biomechanics! The paper titled “Pulmonary arterial strain- and remodeling-induced stiffening are differentiated in a chronic model of pulmonary hypertension ” reports our finding that chronic thromboembolic pulmonary hypertension causes stiffening of the large elastic arteries and that this is correlated with changes in their structure.
Pulmonary hypertension is high blood pressure in the lung vessels that can ultimately lead to heart failure. There is currently no cure for pulmonary hypertension and the prognosis for these patients is pretty grim. 66% of patients die within five years of their diagnosis. Understanding the factors that contribute to the development of pulmonary hypertension will hopefully lead to new treatments for this devastating.
Multiple myeloma is an incurable plasma cancer and the second most common blood malignancy. We have been interested in the role oxygen plays in mediating the progression of this disease and our new collaboration with the Translational Myeloma Group at the University of Iowa has yielded it’s first publication in the journal Oncotarget. We are glad to have had the opportunity to help the Zhan Laboratory with the effort. Our paper titled “Alteration of Mitochondrial Biogenesis Promotes Disease Progression in Multiple Myeloma” should be available soon!